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KMID : 0604620090160010342
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Dongguk Journal of Medicine
2009 Volume.16 No. 1 p.342 ~ p.347
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A Case of Topical Application of Bevacizumab on Corneal Neovascularization after Herpes Keratitis
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Seok Su-Sie
Suh Eok-Soo
Jung Bo-Young
Kim Ho-Chang
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Abstract
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Corneal neovascularization occur as a result of disequilibrium between angiogenic and antiangiogenic stimuli, caused by inflammation, ischemia and truama. VEFG is a important factor of corneal neovascularization. 64 year-old man with herpetic keratitis presented with a complant of decreased vision. He also presented with ocular surface inflammation and corneal new vessels on the whole cornea. He received 1.25% topical bevacizumab twice daily that is directed against VGEF. Ophthalmic evaluation included visual acuity and slit-lamp examination. 4 months later, topically administered bevacizumab reduces corneal new vessles and corneal opacity.
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KEYWORD
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bevacizumab, corneal neovascularization, herpes keratitis
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